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Decreasing expression of glucose‐regulated protein GRP78/BiP as a significant prognostic predictor in patients with advanced laryngeal squamous cell carcinoma
Authors:Kyoichi Kaira MD  Hisao Imai MD  Koichi Sakakura MD  Osamu Nikkuni MD  Masami Suzuki MD  Misa Iijima MD  Takayuki Asao MD  Kazuaki Chikamatsu MD
Affiliation:1. Department of Oncology Clinical Development, Gunma University Graduate School of Medicine, Gunma, JapanKyoichi Kaira, Minoru Toyoda, and Akira Shimizu contributed equally to this work.;2. Department of Respiratory Medicine, Gunma Prefectural Cancer Center, Gunma, Japan;3. Department of Otolaryngology – Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan;4. Department of Head and Neck Surgery, Gunma Prefectural Cancer Center, Gunma, Japan;5. Department of Pathology and Clinical Laboratories, Gunma Prefectural Cancer Center, Gunma, Japan;6. Department of Oncology Clinical Development, Gunma University Graduate School of Medicine, Gunma, Japan
Abstract:
Keywords:endoplasmic reticulum stress  glucose‐regulated protein 78 (GRP78)  immunoglobulin heavy chain binding protein (BiP)  laryngeal cancer  squamous cell carcinoma  immunohistochemistry
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