| 心房肽对高血压模型鼠（SHR）免疫细胞内钙离子浓度的影响 |
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| 引用本文： | 夏邦顺,杨贵贞.心房肽对高血压模型鼠（SHR）免疫细胞内钙离子浓度的影响[J].中国免疫学杂志,1990,6(3):135-137. |
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| 作者姓名： | 夏邦顺 杨贵贞 |
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| 作者单位： | 白求恩医科大学免疫学教研室，白求恩医科大学免疫学教研室 长春 130021，长春 130021 |
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| 摘 要： | 本文探讨了心房肽对自发性高血压大鼠免疫细胞内钙离子浓度的影响,结果表明,心房肽可直接促进大鼠胸腺、脾及淋巴结细胞内的钙离子浓度,亦能协同ConA促进大鼠脾细胞及T细胞内Ca~(2+)浓度的增加,但却不能影响B细胞的Ca~(2+)含量.心房肽还能协同IL-2促进经ConA诱导的大鼠淋巴母细胞内Ca~(2+)浓度的增加。同时发现自发性高血压大鼠免疫细胞心房肽所增加的Ca~(2+)浓度较正常血压对照鼠为低.
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| 关 键 词： | 心房肽 免疫细胞 钙离子 高血压 |
Effect of artrial natriuretic polypeptides on intracellular free calcium concentration in immune cells of spontaneously hypertensive rats |
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| Xia Bangshun,Yang Guizhen.Effect of artrial natriuretic polypeptides on intracellular free calcium concentration in immune cells of spontaneously hypertensive rats[J].Chinese Journal of Immunology,1990,6(3):135-137. |
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| Authors: | Xia Bangshun Yang Guizhen |
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| Institution: | Xia Bangshun,Yang Guizhen Department of Immunology,Norman Bethune University of Medical Sciences,Changchun 130021 |
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| Abstract: | The effect of artrial natriuretic polypeptides on the intracellular free. calcium concentration of immune cells of spontaneously hypertensive rats has been investigated. It was found that artrial natriuretic polypeptides could raise directly the intracellular free calcium concentration of thymocytes, splenocytes and lymphonode cell, or cooperate with Con A in increasing the intracellular free calcium concentration of rat lymphocytes and T lymphocytes except for B cells. It was also found that artrial natriuretic polypeptides could cooperate with IL-2 in increasing the intracellular free calcium concentration of rat lymphoblast induced by Con A. The extent of increased intracellular free calcium concentration induced by artrial natriuretic polypeptides in immune cells of spontaneously hypertensive rats was lower than that of WKA rats. |
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| Keywords: | Artrial natriuretic polypeptides Immune cells Intracellular free calcium Spontaneously hypertensive rat |
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