Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma |
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| Authors: | Furihata Tomomi Hosokawa Masakiyo Fujii Ayako Derbel Maher Satoh Tetsuo Chiba Kan |
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| Affiliation: | Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan. |
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| Abstract: | |
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| Keywords: | CES, carboxylesterase CES RH1, rat carboxylesterase RH1 CES RL1, rat carboxylesterase RL1 CES RL4, rat carboxylesterase RL4 Dex, dexamethasone ESI/MS/MS, electrospray ionization tandem mass spectrometory MPHS, methylprednisolone hemisuccinate Ms, microsomes PNPA, p-nitrophenylacetate SDS-PAGE, sodium dodecyl sulphate-polyacrylamide gel electrophoresis |
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