C反应蛋白在社区获得性肺炎诊断中的意义

目的研究C反应蛋白(C-reative protein,CRP)在社区获得性肺炎诊断中的意义。方法选择2009年8月—2012年8月收治的社区获得性肺炎患者120例作为观察组,同时,随机抽取80名健康体检者作为对照组,两组均于入院24 h内清晨空腹抽取静脉血,分离血清,测定WBC;每日测量体温3⁴次,取其平均值;采用上海蓝怡科技有限公司的试剂盒,用乳胶免疫比浊法测定血清CRP,CRP的正常上限为8 mg/L。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组CRP>8 mg/L者占95.0%,WBC>10×109/L者占20.0%,体温>36.8℃者占71.7%;对照组CRP、WBC、体温均正常。观察组CRP、WBC、体温分别为(48.31±20.34)mg/L、(9.88±2.34)×109/L、(38.10±0.62)℃,对照组分别为(4.62±2.17)mg/L、(5.34±1.29)×109/L、(36.83±0.15)℃,两组比较差异均有统计学意义(均P<0.05)。结论CRP是辅助诊断社区获得性肺炎有效、敏感的指标,具有重要的临床意义。

Significance of C-reactive protein in the diagnosis of community-acquired pneumonia

Objective To study the significance of C-reactive protein（CRP） in community-acquired pneumonia（CAP）.Methods 120 cases of community-acquired pneumonia treated from August 2009 to August 2012 were selected as observation group. At the same time,80 healthy controls were randomly selected.Both groups were examined for fasting venous blood within 24 h on admission,serum was separated and then measured for WBC count.Meanwhile,body temperature was taken in both groups 3-4 times per day.Latex immune nephelometry was used to measure the serum level of CRP,and the upper limit of normal CRP was 8 mg/L. T-test was used for processing measurement data and χ^2 test for count data;P〈0.05 indicated that the difference was statistically significant.Results In observation group,those with CRP〉8 mg/L accounted for 95.0%,those with WBC 〉10 ×10^9/L for 20.0%, and those with body temperature〉36.8℃ for 71.7%;In control group,CRP,WBC and body temperature were normal.The serum level of CRP,WBC count and body temperature were（48.31 ± 20.34）mg/L,（9.88 ± 2.34） × 109/L and（38.10 ± 0.62）℃ respectively in observation group and（4.62 ± 2.IT）rag/L,（5.34 ± 1.29）× 109/L and（36.83 ± 0.15）℃ respectively in control group.Significant difference was found between the two groups （all P〈0.05）.Conclusion Serum levels of CRP are sensitive indicators to auxiliary diagnosis of community-acquired pneumonia,which are of clinical significance.