| 自噬的调控及其对肿瘤的作用 |
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| 引用本文： | 阳丽君,郑志竑. 自噬的调控及其对肿瘤的作用[J]. 医学综述, 2012, 0(20): 3388-3390 |
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| 作者姓名： | 阳丽君 郑志竑 |
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| 作者单位： | 福建医科大学基础医学院生物化学与分子生物学系 |
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| 摘 要： | 自噬是广泛存在于真核细胞内的一种溶酶体依赖性降解途径,是细胞维持稳态的一种机制,在促进细胞生存方面发挥重要作用,其广泛参与细胞的生理和病理过程。根据信号调控自噬主要分为依赖mTOR的自噬和不依赖mTOR的自噬。自噬活性的改变存在于多种人类肿瘤中,自噬在肿瘤的发生、发展过程中起到了促进和抑制的双重作用。随着对自噬研究的深入,有望通过调节自噬达到预防和治疗肿瘤的目的。
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| 关 键 词： | 自噬 机制 信号调控 肿瘤 |
The Regulation of Autophagy and Its Effect on Cancer |
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| YANG Li-jun,ZHENG Zhi-hong. The Regulation of Autophagy and Its Effect on Cancer[J]. Medical Recapitulate, 2012, 0(20): 3388-3390 |
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| Authors: | YANG Li-jun ZHENG Zhi-hong |
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| Affiliation: | .(Department of Biochemistry and Molecular Biology,School of Basic Medicine of Fujian Medical University,Fuzhou 350004,China) |
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| Abstract: | Autophagy is lysosomal-dependent degradation widely existing in eukaryotic cells,which is a mechanism to maintain homeostasis and plays an important role in promoting cell survival.Autophagy is widely involved in cell physiological and pathological processes.Signal-dependent regulated autophagy is divided into the mTOR-dependent autophagy and mTOR-independent autophagy.The change of autophagic activity is in a variety of human tumors and plays a dual role for the promotion and inhibition in tumor occurrence and development.Along with the deeper study of autophagy,prevention and treatment of tumor by adjusting autophagy is expected. |
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| Keywords: | Autophagy Mechanism Signal-regulated Tumor |
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