硫普罗宁治疗慢性乙型肝炎的临床疗效评价

目的探讨硫普罗宁对慢性乙型肝炎的治疗效果及安全性。方法将慢性乙型肝炎84例,随机分为两组。对照组42例,以肌苷0.6g,维生素C2.0g,维生素B60.2g加入5%葡萄糖溶液250ml中静脉滴注,1次/d,连续治疗4周;治疗组42例,以硫普罗宁0.2g加入5%葡萄糖溶液250ml中静滴,1次/d,连续治疗4周,同时分别监测肝功能指标：丙氨酸氨基转移酶（ALT）,天冬氨酸转移酶（AST）、总蛋白（TP）、总胆红素（TBI）、总胆汁酸（TBA）等,并进行比较。结果硫普罗宁治疗组较对照组在肝功能复常方面显示良好的治疗效应,使转氨酶明显下降,两组显效率分别为50%（21/42）和30%（13/42）,总有效率为84%（35/42）和50%（21/42）,两组比较差异有显著性（P〈0.01）。结论短期临床研究提示硫普罗宁治疗慢性乙型肝炎,可明显改善肝功能,且不良反应少,疗效显著。

The evaluation of tiopronin in the treatment of chronic hepatitis B

Objective To explore the therapeutic effects and safety of tiopronin on chronic hepatitis B （CHB）. Methods 84 cases CHB were derided randomly into two groups on the average. The control group was treated by inosinum 0.6 g, vitamin C 2.0 g and vitamin B6 0.2 g with intravenous drip once a day for four weeks. The treatment group was treated by tiopronin 0.2 g with intravenous drip once a day for four weeks. , and liver function including alanine aminotransferase （ALT） and aspartate aminotransferase （AST） activities , the levels of serum total protein （TP）, total bilirubin （TBi）, and total bile acid （TBA） were measured respectively. The results of two groups were compared. Results the therapeutic effects of the treatment group were evidently prior to the control group in recovering liver function and clinical symptoms improved obviously in treatment group . Treatment with the drug was associated with a significant improvement in abnormalities of serum transaminase. The obvious effective rates were 50% （21/42）in the treatment group ,and 30% （13/42）in the control group , respectively. The total effective rates were 84% （35/42）in the former and 50% （21/42）in the later, respectively. Significant difference in therapeutic effects was found between the two groups （ P 〈 0.01 ）. Conclusion The present data suggest that tiopronin improves the liver function with few side effects and has a good therapeutic effect on patients with CHB during short -term study.