Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase |
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| Authors: | Kim Do-Sung Kim Hyung-Ryong Woo Eun-Rhan Hong Seong-Tshool Chae Han-Jung Chae Soo-Wan |
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| Affiliation: | Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk 560-180, South Korea. |
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| Abstract: | |
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| Keywords: | ADR, ADR AP-1, activator protein-1 BCA, bicinchoninic acid CAT, catalase DiOC6(3), 3,3′-diexyloxocarbocyanine iodide DMEM, Dulbecco's modified Eagle's medium DMSO, dimethyl sulfoxide DN, dominant negative EMSA, electrophoretic mobility shift assay ERK, extracellular signal-regulated kinase FBS, fetal bovine serum GSH, glutathione JNK, c-Jun N-terminal Kinase MAN, mannitol MAPK, mitogen-activated protein kinase NAC, N-acetyl-cysteine RA, rosmarinic acid ROS, reactive oxygen species SOD, superoxide dismutase |
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