急性缺血性脑血管病患者血清氧化型低密度脂蛋白抗体的检测

目的探讨氧化型低密度脂蛋白抗体检测在急性脑缺血发生发展过程中的作用及诊断价值。方法选择我院2007年6月~8月住院的急性脑缺血患者80例,根据发病时头颅磁共振检查结果,将患者分为急性脑梗死组与短暂脑缺血组,采用酶联免疫吸附法同时测定二组血清氧化型低密度脂蛋白抗体,检测血清生物化学各项指标,并对结果进行统计学分析。结果急性脑梗死组血清氧化型低密度脂蛋白抗体为38.07±32.14ku/L,短暂脑缺血组为25.18±9.17ku/L,二组比较有显著性差异(P<0.05);而与其它生物化学学指标无相关性。结论氧化型低密度脂蛋白抗体水平在不同类型脑缺血中有所不同,其升高有可能是急性脑梗死的危险信号。

Detection of Blood Serum Oxidized Low Density Lipoprotein Antibody in Patients with Acute Cerebrovascular Ischemia

Aim To evaluate the effect and diagnosis value on oxidized low density lipoprotein (ox-LDL) in the developing process of acute cerebral ischemia. Methods Eighty acute cerebral ischemia patients were chosen during June to August, 2007. These patients were divided two groups: the acute cerebral infarction (ACI) group and transient ischemic attack (TIA) group, based on the functional MR examination. The serum ox-LDL antibody was tested by enzyme-linked immunosorbent assay (ELISA) method, the main serum biochemistry indexes were detected to all patients and statistics analysis was performed. Results The patients in ACI group had a 38.07±32.14 ku/L ox-LDL antibody level and in TIA group had a 25.18±9.17 ku/L ox-LDL antibody level. A significant difference as compared with the patients in the twe group (P<0.05). The other biochemics index had no dependability in the two groups. Conclusions The patients with The ox-LDL antibody level is distinct in different type of cerebral ischemia patients and a higher level may give a danger signal with acute cerebra infarction.