New derivatives of CNC-amino acids and -oligopeptides: Experimental antitumor activity |
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Authors: | W. J. Zeller |
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Affiliation: | (1) Institute of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 280, D-6900 Heidelberg, Federal Republic of Germany |
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Abstract: | Summary The experimental antitumor activity of a series of new nitrosoureas is described in which the chloroethylnitrosocarbamoyl (CNC) group is attached to different carrier molecules: amino acids and oligopeptides.Of a group of 10 CNC-amino acid amide derivatives the majority displayed high therapeutic activity in L 5222 leukemia. Some compounds, especialy the proline and sarcosine derivatives, showed favorable therapeutic ratios; 12 CNC-oligopeptides displayed a more or less pronounced therapeutic activity in L 1210 leukemia. Compounds bearing a free carboxy group were less active than the corresponding unsubstituted or N-methyl substituted amides.Dedicated to Professor Dietrich Schmähl on the occasion of his 60th birthday |
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Keywords: | Nitrosoureas Amino acids Oligopeptides L 5222 leukemia L 1210 leukemia |
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