Synthesis, spectral, crystal structure and in vitro antimicrobial evaluation of imidazole/benzotriazole substituted piperidin-4-one derivatives期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis, spectral, crystal structure and in vitro antimicrobial evaluation of imidazole/benzotriazole substituted piperidin-4-one derivatives

Authors:	Ramachandran R Rani M Senthan S Jeong Yeon Tae Kabilan S

Affiliation:	^a Department of Chemistry, Annamalai University, Annamalainagar - 608 002, Tamil Nadu, India ^b Department of Image Science and Engineering, Pukyong National University, Busan 608-737, Republic of Korea

Abstract:	Imidazole/benzotriazole analogues substituted piperidin-4-one derivatives (17-26) have been synthesized. Their chemical structures were characterized by IR, ¹H NMR, ¹³C NMR and mass spectral analysis. In addition, single crystal X-ray diffraction has also been recorded for compounds 21 and 23. The synthesized compounds were subjected to their in vitro antibacterial and antifungal activities against pathogenic microbial strains. The results pointed out that compounds 19 & 24 against B. subtilis and 20 & 24 against E. coli were explored superior inhibition activity.

Keywords:	2,6-Diarylpiperidin-4-ones Imidazoles Benzotriazole Antimicrobial activity
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