Chemical composition and cytotoxic activity of the leaf essential oil of <Emphasis Type="Italic">Eugenia zuchowskiae</Emphasis> from Monteverde,Costa Rica |
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| Authors: | Ramona A Cole Anita Bansal Debra M Moriarity William A Haber William N Setzer |
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| Institution: | (1) Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA;(2) Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA;(3) Missouri Botanical Garden, St. Louis, MO 63166, USA;(4) Apdo. 50-5655, Monteverde, Puntarenas, Costa Rica |
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| Abstract: | The leaf essential oil of Eugenia zuchowskiae from Monteverde, Costa Rica, has been obtained by hydrodistillation and analyzed by GC–MS. The principal constituents of
E. zuchowskiae leaf oil were α-pinene (28.3%), β-caryophyllene (13.2%), α-humulene (13.1%), and α-copaene (8.1%). The leaf essential oil
of E. zuchowskiae showed pronounced in-vitro cytotoxic activity against MCF-7, MDA-MB-468, and UACC-257 human tumor cell lines. The major components
showed cytotoxic activities comparable to doxorubicin (LC50 14–70 μg/ml). |
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| Keywords: | Eugenia zuchowskiae Essential oil Chemical composition Cytotoxicity |
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