| 白介素与骨关节炎 |
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| 引用本文： | 徐东红,沈炜明.白介素与骨关节炎[J].药学服务与研究,2005,5(1):82-85. |
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| 作者姓名： | 徐东红 沈炜明 |
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| 作者单位： | 上海交通大学附属第六人民医院药剂科,上海,200233 |
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| 摘 要： | 骨关节炎(OA)为老年人中的常见病,其病因及发病机制尚未完全明确。目前认为OA继发性滑膜炎的存在是OA慢性持续化的重要原因。在滑膜炎症释放的炎性介质中,白介素(IL)起了重要作用。本文介绍了IL的种类、信号传导、生物学功能以及IL-1、IL-6、IL-11、IL-12、IL-13等与OA的关系,及OA的抗IL治疗。
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| 关 键 词： | 骨关节炎 白细胞介素 抗白介素治疗 综述 |
| 文章编号： | 1671-2838(2005)01-0082-04 |
| 修稿时间： | 2004年6月22日 |
Interleukines and osteoarthritis |
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| XU Dong-Hong,SHEN Wei-Ming.Interleukines and osteoarthritis[J].Pharmaceutical Care and Research,2005,5(1):82-85. |
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| Authors: | XU Dong-Hong SHEN Wei-Ming |
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| Abstract: | Osteoarthritis(OA) is very common in old people. It's etiology and pathogenisis are not completely ascertained. It is considered that the secondary inflammation of synovium is very important in maintaining articular cartilage damage. A-mong the inflammatory mediators, interleukins play an important role. So the category, signal transmission, and biological function of interleukins as well as the correlation between some interleukins and OA are reviewed. In addition, the anti-inter-leukin treatment of OA is introduced. |
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| Keywords: | osteoarthritis interleukins anti-interleukin treatment review |
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