Stimulation of arachidonic acid metabolism by human slow-reacting substances. |
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| Authors: | J P Seale P J Piper |
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| Affiliation: | Department of Pharmacology, INstitute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln''s In Field, London WC2A 3 PN, U.K. |
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| Abstract: | Human slow-reacting substance of anaphylaxis (SRS-A) and calcium ionophore-induced human SRS released prostaglandin-like substances and rabbit aorta contracting substance (RCS) from guinea-pig lungs. This effect was abolished by incubation of SRS-A and SRS with arylsulphatase or pretreatment of the lungs with indomethacin. Human SRS-A and SRS therefore resembled guinea-pig SRS-A in stimulating arachidonic acid metabolism. These results provide further evidence for a similar (or identical) nature of human SRS-A and SRS and suggest a possible role for slow-reacting substances in the release of prostaglandins during anaphylaxis. |
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| Keywords: | Human slow-reacting substances Calcium ionophore Arachidonate metabolism |
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