抑郁症患者血中T细胞亚群数量及相关因素的研究

目的：研究抑郁症患者外周血中T细胞亚群的变化及相关因素，探讨抑郁症患者的免疫功能变化，为治疗提供新的依据。方法：应用碱性磷酸酶标记链霉卵白素法检测32例抑郁症患者和32例健康对照血中T细胞亚群数量及构成比，并与其相关因素进行多元线性回归分析。结果：1．与对照组相比，抑郁症患者血中CD3^ 、CD4^ 细胞数以及CD4^ ／CD8^ 比值明显降低，而CD8^ 细胞数明显升高。2．男性患者与抑郁症患者总体改变相同。而女性患者血中CD3^ 、CD4^ 细胞数、CD8^ 细胞数以及CD4^ ／CD8^ 比值与对照组比较差异不显著；3．多元线性回归结果：抑郁症患者血中CD8^ 细胞数与病程呈非常显著负相关。结论：抑郁症患者免疫功能低下，其免疫功能低下可能能有性别差异，而且抑郁症患者的免疫功能变化可能与病程有关。

Study on the Number of T Cell Subpopulations and Relevant Factors for Depression Patients

Objective:To explore the cause and pathological mechanism of depression by detecting the number of T cell subpopulation in patients' venous blood.Methods:32 depression patients and 32 healthy persons of matched ages as normal controls were selected for the study. The numbers of T Cell subpopulations and their component ratio i.e. the numbers of CD3 cells, CD4 cells and CD8 cells and the ratio of CD 4 / CD 8 cells in their venous blood were detected by SAP method. Results: (1)As compared with that of the controls,the numbers of CD3 and CD4 Cells and the ratio of CD4 /CD8 decreased, while the number of CD8 cells increased obviously in blood of depression patients.(2)The change of male patients were similar to the general change of depression patients;while there were no significant change in the numbers of CD3 ,CD4 ,CD8 and the ratio of CD4 /CD8 in female patients.(3)The multifactor linear regression analysis showed that the number of CD8 cells was significantly negatively correlated to the disease course . Conclusion: Severe immune function disorders were found in depression patients,with difference in sex,and that disorder may be related to the disease course.