| 全饥饿对大鼠外周血抗氧化防御系统功能的影响 |
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| 引用本文： | 杨继军,郭长江,韦京豫,蒋与刚,李云峰. 全饥饿对大鼠外周血抗氧化防御系统功能的影响[J]. 解放军预防医学杂志, 2004, 22(2): 90-92 |
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| 作者姓名： | 杨继军 郭长江 韦京豫 蒋与刚 李云峰 |
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| 作者单位： | 军事医学科学院卫生学环境医学研究所,天津,300050;军事医学科学院卫生学环境医学研究所,天津,300050;军事医学科学院卫生学环境医学研究所,天津,300050;军事医学科学院卫生学环境医学研究所,天津,300050;军事医学科学院卫生学环境医学研究所,天津,300050 |
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| 基金项目： | 军事医学科学院创新基金资助课题 (No .0 10 43 1) |
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| 摘 要： | 目的 探讨饥饿后外周血抗氧化防御系统功能的变化。方法 通过禁食大鼠造成饥饿，观察外周血红细胞还原性谷胱甘肽(GSH)含量、血清总抗氧化力、总超氧化物歧化酶(T—SOD)与谷胱甘肽过氧化物酶(GSHPx)．活性以及丙二醛(MDA)含量变化。结果 饥饿10d后，血清总抗氧化力及T—SOD与GSHPx活性显著下降，下降幅度分别为13．8％、8．5％、5．7％；血清MDA含量同时也显著下降，而红细胞GSH含量无显著变化。结论 全饥饿可使外周血抗氧化防御系统功能下降。
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| 关 键 词： | 饥饿 血液 抗氧化力 |
| 文章编号： | 1001-5248(2004)02-0090-03 |
| 修稿时间： | 2003-04-11 |
FUNCTIONAL CHANGES OF PERIPHERAL BLOOD ANTIOXIDATIVE DEFENSE SYSTEM AFTER STARVATION IN RATS |
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| YANG Ji-jun,GUO Chang-jiang,WEI Jing-yu,JIANG Yu-gang,LI Yun-feng. FUNCTIONAL CHANGES OF PERIPHERAL BLOOD ANTIOXIDATIVE DEFENSE SYSTEM AFTER STARVATION IN RATS[J]. Journal of Preventive Medicine of Chinese People's Liberation Army, 2004, 22(2): 90-92 |
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| Authors: | YANG Ji-jun GUO Chang-jiang WEI Jing-yu JIANG Yu-gang LI Yun-feng |
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| Abstract: | Objective To investigate functional changes of peripheral blood antioxidative defense system after starvation. Methods Starvation was induced in rats by fasting. The peripheral blood GSH content,total SOD and GSHPx activities, MDA content,and plasma total antioxidant capacity were measured. Results After 10 d of starvation, plasma total antioxidant capacity, total SOD and GSHPx activities significantly decreased by 13.8%, 8.5%, 5.7% respectively in starvation group but did not decrease in normal control group. MDA content was also decreased. Blood GSH content was not significantly changed by 10 d starvation. Conclusion Starvation may induce damage to the function of antioxidative defense system in peripheral blood. |
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| Keywords: | starvation blood antioxidant capacity |
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