| 氧分压与二氧化碳分压对离体豚鼠心肌收缩性的影响 |
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| 引用本文： | 杨光田,S. Daum. 氧分压与二氧化碳分压对离体豚鼠心肌收缩性的影响[J]. 华中科技大学学报(医学版), 1986, 0(5) |
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| 作者姓名： | 杨光田 S. Daum |
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| 作者单位： | 同济医科大学基础医学部病理生理学教研室(杨光田)，联邦德国慕尼黑科技大学教学医院(S. Daum) |
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| 摘 要： | 用改良的Langendorff方法灌注离体豚鼠心脏冠状动脉,观察灌注液氧分压(PO_2)与二氧化碳分压(PCO_2)变化对左、右心室心肌收缩性的影响。结果表明PCO_2增高可使左、右心室的收缩压及压力上升的最大速度(dp/dt max)明显降低,PO_2降低可使左、右心室的收缩压及dp/dt max明显降低。PO_2降低合并PCO_2增高较单纯性缺氧或单纯性PCO_2增高对心肌收缩性的影响更大。
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| 关 键 词： | 氧分压 二氧化碳分压 心肌收缩性 |
Effects of PO2 and PCO2 on Myocardial Contractility of the Isolated Guinea Pig Heart |
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| Yang Guangtian. Effects of PO2 and PCO2 on Myocardial Contractility of the Isolated Guinea Pig Heart[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1986, 0(5) |
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| Authors: | Yang Guangtian |
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| Affiliation: | Yang Guangtian Department of Pathophysiology,Tongji Medical University,WuhanSeverin DaumTeaching Hospital,Technical University of Munich,Federal Republic of Germany |
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| Abstract: | Isolated hearts of 20 guinea pigs were perfused via coronary arteries with a modified Langendorff method in order to determine the effects of PO2 and PCO2 on the contractility of the left and right ventricular myocardium.The results showed that the systolic pressure of both ventricles and the rate of rise of left ventricular pressure (dp/dt) could be markedly reduced with either a perfusate of high PCO2 or a perfusate of low PO2.The increased PCO2 could also cause a decline of the rate of rise of right ventricular pressure (dp/dt).The depressive effect of combined hypoxia and hypercapnia on the myocardial contractility was more prominent than that of either hypoxia or hypercapnia alone. |
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| Keywords: | PO_2 PCO_2 myocardial contractility |
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