| 大黄附子汤的镇痛作用和对阳虚便秘动物肠运动的影响 |
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| 引用本文： | 刘管理,李国成,张俊芳. 大黄附子汤的镇痛作用和对阳虚便秘动物肠运动的影响[J]. 广东药学院学报, 2009, 25(3): 292-294 |
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| 作者姓名： | 刘管理 李国成 张俊芳 |
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| 作者单位： | 广东省人民医院,药学部/广东省医学科学院,广东,广州,510080;中山大学附属第二医院,药学部,广东,广州,510120 |
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| 摘 要： | 目的探讨大黄附子汤对实验动物的镇痛和对阳虚便秘动物肠运动的作用。方法通过小鼠冰乙酸扭体试验，观察该方的镇痛作用；应用山西白醋加活性炭冰水法制作阳虚便秘动物模型。观察大黄附子汤对阳虚便秘小鼠的排便时间、排便量、小肠推进作用的影响和对大鼠在体回肠活动的影响。结果大黄附子汤中、高剂量有显著的镇痛作用；阳虚便秘动物肠运动试验中，大黄附子汤各剂量组与模型组比较，各组动物的首粒排便时间显著缩短，3h内排便粒数显著增加，小肠推进率明显提高；在给药10～15min后，在体回肠蠕动明显增强。结论大黄附子汤对实验动物有明显的通便和镇痛作用，其通便作用可能与大黄附子汤促进动物肠肌运动有关。
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| 关 键 词： | 大黄附子汤 镇痛 阳虚 便秘 回肠 |
Effects of Rhei Aconiti Praeparatae Decoction on bowel movement of animals with constipation due to yang asthenia and its analgesic effects |
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| LIU Guan-li,LI Guo-cheng,ZHANG Jun-fang. Effects of Rhei Aconiti Praeparatae Decoction on bowel movement of animals with constipation due to yang asthenia and its analgesic effects[J]. Academic Journal of Guangdong College of Pharmacy, 2009, 25(3): 292-294 |
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| Authors: | LIU Guan-li LI Guo-cheng ZHANG Jun-fang |
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| Affiliation: | LIU Guan-li1,LI Guo-cheng2,ZHANG Jun-fang1 (1.Department of Pharmacy,Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences,Guangzhou 510080,China,2.Department of Pharmacy,The Second Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510120,China) |
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| Abstract: | Objective To investigate the effects of Rhei Aconiti Praeparatae Decoction on bowel movement of animals with constipation due to yang asthenia and its analgesic effects.Methods To observe analgesic effects of Rhei Aconiti Praeparatae Decoction with abdominal constriction test induced by acetic acid in mice.And to observe the effects of Rhei Aconiti Praeparatae Decoction on the time and number of excreting stool,gastrointestinal movement,ileum peristalsis in rats in vivo.Results Rhei Aconiti Praeparatae Deco... |
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| Keywords: | Rhei Aconiti Praeparatae Decoction yang asthenia constipation ileum |
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