| 南葶苈子化学拆分工艺研究 |
| |
| 引用本文： | 张明辉,张艳丽,赵威,王小兰,冯卫生,匡海学,郑晓珂. 南葶苈子化学拆分工艺研究[J]. 世界科学技术-中医药现代化, 2015, 17(3): 476-484 |
| |
| 作者姓名： | 张明辉 张艳丽 赵威 王小兰 冯卫生 匡海学 郑晓珂 |
| |
| 作者单位： | 河南中医学院药学院 郑州 450046；呼吸疾病诊疗与新药研发河南省协同创新中心 郑州 450046,河南中医学院药学院 郑州 450046；呼吸疾病诊疗与新药研发河南省协同创新中心 郑州 450046,河南中医学院药学院 郑州 450046；呼吸疾病诊疗与新药研发河南省协同创新中心 郑州 450046,河南中医学院药学院 郑州 450046；呼吸疾病诊疗与新药研发河南省协同创新中心 郑州 450046,河南中医学院药学院 郑州 450046；呼吸疾病诊疗与新药研发河南省协同创新中心 郑州 450046,黑龙江中医药大学药学院 哈尔滨 150040,河南中医学院药学院 郑州 450046；呼吸疾病诊疗与新药研发河南省协同创新中心 郑州 450046 |
| |
| 基金项目： | 科学技术部国家重点基础研究发展计划“973 计划”项目（2013CB531802）：宣泻利水中药的药性研究，负责人：郑晓珂。 |
| |
| 摘 要： | 目的:建立南葶苈子的化学组分拆分方法,并对拆分组分进行稳定性和互不交叉性考察。方法:采用煎煮、蒸馏、萃取、醇沉、大孔吸附树脂等技术获得南葶苈子拆分组分,采用HPLC及化学计量学软件进行稳定性和互不交叉性评价。结果:将南葶苈子拆分为6个组分,HPLC色谱数据及化学计量学分析结果显示拆分工艺稳定,各拆分组分互不交叉,符合可拆分可组合的研究模式。结论:建立了南葶苈子化学组分拆分方法,各拆分组分互不交叉,工艺稳定性、重现性良好。
|
| 关 键 词： | 南葶苈子 化学组分拆分 互不交叉 化学计量学分析 |
| 收稿时间： | 2015-02-20 |
| 修稿时间： | 2015-03-10 |
Research on Fraction-splitting Technology of Seeds of Descurainia Sophia |
| |
| Zhang Minghui,Zhang Yanli,Zhao Wei,Wang Xiaolan,Feng Weisheng,Kuang Haixue and Zheng Xiaoke. Research on Fraction-splitting Technology of Seeds of Descurainia Sophia[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2015, 17(3): 476-484 |
| |
| Authors: | Zhang Minghui Zhang Yanli Zhao Wei Wang Xiaolan Feng Weisheng Kuang Haixue Zheng Xiaoke |
| |
| Affiliation: | School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China;Collaborative Innovation Center for Respiratory Disease Diagnosis And Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China,College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China and School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China;Collaborative Innovation Center for Respiratory Disease Diagnosis And Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China |
| |
| Abstract: | This study was aimed to establish the method for fraction-splitting of seeds of Descurainia sophia, in order to study the stability and unoverlapping property of fractions of seeds of D. sophia. The fraction-splitting of seeds of D. sophia were obtained through the combination of various methods including decoction, distillation, extraction, ethanol precipitation and gradient elution of macroporous adsorption resin. HPLC and chemometrics software were used to analyze the stability and unoverlapping property of the fractions of D. sophia. The results showed that the chemical components from seeds of D. sophia was divided into six fractions. HPLC data and chemometrics analysis showed good stability of technology. The fraction-splitting of seeds of D. sophia was unoverlapping. It complied with the research model of chemical constituents of seeds of D. sophia which can be split and combinatorial. It was concluded that the established method for splitting fractions of seeds of D. sophia had good stability and repeatability. Each splitting fraction uncrossed others. |
| |
| Keywords: | Seeds of Descurainia sophia divided chemical constituent unoverlapping chemometrics analysis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《世界科学技术-中医药现代化》浏览原始摘要信息 |
|
点击此处可从《世界科学技术-中医药现代化》下载全文 |
|
