六味地黄丸联合氯沙坦钾治疗早期糖尿病肾病的临床研究

目的观察六味地黄丸联合氯沙坦钾治疗早期糖尿病肾病的临床疗效。方法选择2010年12月—2014年8月滦平县中医院收治的早期糖尿病肾病患者100例,随机分为治疗组与对照组,每组50例。对照组口服氯沙坦钾片50 mg/次,1次/d。治疗组患者在对照组的基础上口服六味地黄丸,9 g/次,2次/d。两组均连续治疗8周。观察两组患者的临床疗效,同时比较两组患者收缩压、舒张压、平均动脉压、血肌酐(Scr)、血尿素氮(BUN)、尿微量蛋白、尿白蛋白排泄率(UAER)、C反应蛋白(CRP)的变化。结果治疗后,对照组和治疗组的总有效率分别为70.0%、92.0%,两组总有效率比较差异有统计学意义(P0.05)。治疗后,两组患者收缩压、舒张压、平均动脉压、Scr、BUN、尿微量蛋白、UAER、CRP均较治疗前显著降低,同组治疗前后差异有统计学意义(P0.05);且治疗后治疗组这些观察指标(除Scr、BUN外)的改善程度优于对照组,两组比较差异有统计学意义(P0.05)。结论六味地黄丸联合氯沙坦钾治疗早期糖尿病肾病具有较好的临床疗效,可改善肾功能,有效降低尿微量蛋白,具有一定的临床推广价值。

Clinical study on Liuwei Dihuang Pills combined with losartan potassium in treatment of early diabetic nephropathy

Objective To investigate the effect of Liuwei Dihuang Pills combined with losartan potassium in treatment of early diabetic nephropathy. Methods Patients (100 cases) with early diabetic nephropathy in Luanping County Hospital of Traditional Chinese Medicine from December 2010 to August 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were po administered with Losartan Potassium Tablets, 50 mg/time, once daily. The patients in the treatment group were po administered with Liuwei Dihuang Pills on the basis of control group, 9 g/time, twice daily. Two groups were treated for eight weeks. After treatment, the efficacy was evaluated, and the changes of systolic pressure, diastolic blood pressure, mean arterial pressure, Scr, BUN, urine micro protein, UAER, and CRP in two groups were compared. Results The efficacies in control and treatment groups were 70.0% and 92.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, systolic pressure, diastolic blood pressure, mean arterial pressure, Scr, BUN, urine micro protein, UAER, and CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these indicators (except Scr and BUN) in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Liuwei Dihuang Pills combined with losartan potassium has good clinical efficacy in treatment of early diabetic nephropathy, and can improve renal function, also can effectively reduce the urine micro protein, which has a certain clinical value.