血清NSE变化与新生儿缺氧缺血性脑病相关性研究

目的研究新生儿窒息后发生脑损伤与血清神经元特异性烯醇化酶（NSE）动态水平变化以及与新生儿HIE的关系。方法实验组为新生儿病房Apgar评分≤3分的新生儿38例，生后观察临产表现及CT检查，结果判断组轻度HIE8例，中度17例，重度13例，并以10例正常足月新生儿做为对照，采用放射免疫分析法，检测生后1、3天天血清NSE水平。结果轻、中、重度组分别与对照组有显著差异（P〈0．01）。轻、中、重度HIE组之间3天内血清NSE比较，有显著差异（P〈0．01）。结论血清NSE水平与HIE的病情严重程度相关，可作为早期诊断中、重度新生儿缺氧缺血性脑病的客观指标。

The level of NSE in blood of newborns with Hypoxic ischemic encephalopathy

Objective To study the changes of Neuron-specific enolase (NSE)in blood of newborns with Hypoxic ischemic encephalopathy and to make out the relationship between the level of NSE in cord blood and the brain damage after neonatal asphyxia. Methods Radioimmunoassay measured serm levels of NSE in postnatal 1,3 days of control group and test group. 10 normal newborns were control group. There were 38 neonates which Apgar score ≤3 server as the test group. Results The results showed that the level of NSE in cord blood of neonates with HIE was significantly higher than normal control(P<0.01).Conclusion The levels of NSE in cord blood are the symbol reflecting the early brain damage.