| 不同剂量巴曲酶对大鼠局灶性脑缺血再灌流后病理改变影响的研究 |
| |
| 引用本文： | 苏志强,刘亢丁,王德生,饶晓俐.不同剂量巴曲酶对大鼠局灶性脑缺血再灌流后病理改变影响的研究[J].中国急救医学,2002,22(6):316-317. |
| |
| 作者姓名： | 苏志强 刘亢丁 王德生 饶晓俐 |
| |
| 作者单位： | 1. 哈尔滨医科大学第一临床医学院神经内科,150001
2. 吉林大学第一临床医学院神经内科 |
| |
| 基金项目： | 黑龙江省 2 0 0 0年自然科学基金资助项目 (No D0 0 67) |
| |
| 摘 要： | 目的 探讨不同剂量巴曲酶对大鼠局灶性及缺血再灌流的保护作用。方法 采用线栓法制备大脑中动脉缺血再灌流模型。利用计量病理学方法进行评价。结果 与对照组相比，巴曲酶组急性型神经元所占比例明显减少（P＜0．01），随着用药剂量增加急性型神经元所占比例呈增加趋势。结论 巴曲酶对脑缺血有保护作用，其保护作用与剂量有关。
|
| 关 键 词： | 局灶性脑缺血 巴曲酶 缺血再灌流 病理学 线栓法 |
| 文章编号： | 1002-1949(2002)06-0316-02 |
| 修稿时间： | 2002年3月15日 |
Influence of diferent dosage Batroxobin on pathological change in rat with focul cerebral ischemia and reperfusion |
| |
| SU Zhi-qiang,LIU Kang-ding,WANG De-sheng,et al..Influence of diferent dosage Batroxobin on pathological change in rat with focul cerebral ischemia and reperfusion[J].Chinese Journal of Critical Care Medicine,2002,22(6):316-317. |
| |
| Authors: | SU Zhi-qiang LIU Kang-ding WANG De-sheng |
| |
| Institution: | SU Zhi-qiang,LIU Kang-ding,WANG De-sheng,et al.Department of Neurology,First Teaching Hospital,Harbin Medical University,Harbin 150001,China |
| |
| Abstract: | Objective To study the protective effect of different dosage Batroxobin after cerebral ischemic reperfusion.Methods The local cerebral ischemic reperfusion model with thread embolism of MCA was made.The quantitative pathological method was used to evalutate ischemic neuronal damage.Results The acute type neurons in Bathroxin groups were increased,the delay type neurons were decreased as compared with control group.Furthermore,the percentage of acute type neurons was ascended as Batroxobin dosages increased.Conclusion Batroxobin had significantly protective effect and related with its dosages. |
| |
| Keywords: | Bathoxobin Cerebral ischemic reperfusion Pathology |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
