Inhibition of the immune response of mouse spleen cells to sheep erythrocytes in vitro by anti-immunoglobulin sera

The effect of anti-immunoglobulin sera on the antibody response of both non-sensitized and sensitized mouse spleen cells in vitro has been studied. Antisera to immunoglobulin Fab gave almost complete inhibition of both IgM and IgG responses. Antisera to IgM suppressed the IgM but not the IgG response and conversely antisera to IgG classes caused some suppression of the IgG response but did not reduce the IgM response. These results have been discussed in terms of the nature of receptor molecules on lymphocytes responsible for recognition of antigen.