神经节苷脂对老龄大鼠急性低压缺氧脑损害的防治作用

目的 观察急性低压缺氧对老龄大鼠脑组织中内皮素（ＥＴ）、一氧化氮（ＮＯ）含量和大脑皮质光、电镜形态学的影响以及神经节苷脂的防治作用。方法 ４０只２２月龄Ｗｉｓｔａｒ大鼠随机分成生理盐水对照组、生理盐水缺氧组和神经节苷脂缺氧组。急性低压缺氧（８０００ｍ，３０ｍｉｎ）前４ｈ各组均腹腔注射相同体积的生理盐水或神经节苷脂（ＧＭ１），测定各组大脑皮质和丘脑匀浆中ＥＴ、ＮＯ的含量，观察大脑皮质光、电镜形态学的

Protective effects of ganglioside GM_1 on brain injury after acute hypobaric hypoxia in old rats

Objective To observe the effect of acute hypoxia on endothelin(ET) and nitric oxide (NO) contents and ultrastructure changes of cerebral cortex in old rats and the protective effect of ganglioside GM 1. Methods Forty 22 month old Wistar rats were divided into normal saline(NS) control group, NS hypoxia group, and ganglioside GM 1 hypoxia group. Ganglioside GM 1(35 mg/kg,i.p.) or NS was given 4 h before entering hypobaric chamber and acute hypoxia exposure (8 000 m ,30 min).The ET and NO contents of cerebral cortex and thalamus were measured and the microscopic and electron miscropic changes of cerebral cortex were examined. Results The ET and NO contents of cerebral cortex and thamulus in NS hypoxia group were significantly higher than those in NS control group ( P<0.01,P <0.05). The ultrastructural changes of cerebral cortex capillaries, perivascular tissue and feltwork in NS control group were prominent, while the changes in GM 1 hypoxia group were not significant as compared with control's. Conclusion It is suggested that, the increase of ET and NO contents of cerebral cortex and thalamus may participate in the pathogenesis of hypoxia brain injury in old rats.Administration of GM 1 before acute hypoxia exposure may protect the old rats from brain injury.