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| 肾毒清冲剂治疗慢性肾功能不全的实验研究 | |
| 引用本文： | 郭秀丽,纪建波,靖新文,胡昭,周勇. 肾毒清冲剂治疗慢性肾功能不全的实验研究[J]. 中成药, 2001, 23(7): 506-508 |
| 作者姓名： | 郭秀丽 纪建波 靖新文 胡昭 周勇 |
| 作者单位： | 1. 山东大学药学院,济南,250012 2. 山东大学齐鲁医院,济南,250012 3. 山东大学第二附属医院,济南,250033 |
| 基金项目： | 山东省科学技术委员会课题,项目编号:981216714 |
| 摘 要： | 目的：观察肾毒清冲剂对慢性肾功能不全大鼠的保护作用。方法：用含0．75％的腺嘌呤（Adenine,Ade)饲料喂养大鼠造成慢性肾功能不全模型。测定血液生化指标、血清离子浓度并观察大鼠肾脏的病理改变。结果：肾毒清明显增加胸腺指数。肾脏重量也明显低于模型组。肾脏组织形态学表明，肾毒清冲剂显著减轻了肾脏病理改变。药物结晶减少。结论：肾毒清冲剂对慢性肾功能不全大鼠有较强的保护作用。 |
| 关 键 词： | 肾毒清冲剂 慢性肾功能不全 肌酐 尿素氮 中药实验药理 |
| 文章编号： | 1001-1528(2001)07-0506-03 |
| 修稿时间： | 2000-10-20 |
Experimental Study on Shenduqing Granules on Chronic Renal Insufficiency |
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| GUO Xiu li ,JI Jian bo ,JING Xin wen ,HU Zhao ,ZHOU Yong. Experimental Study on Shenduqing Granules on Chronic Renal Insufficiency[J]. Chinese Traditional Patent Medicine, 2001, 23(7): 506-508 | |
| Authors: | GUO Xiu li JI Jian bo JING Xin wen HU Zhao ZHOU Yong |
| Affiliation: | GUO Xiu li 1,JI Jian bo 1,JING Xin wen 2,HU Zhao 2,ZHOU Yong 3 |
| Abstract: | Objective: To investigate the protective effect of shenduqing Granules on chronic renal insufficiency in rats. Methods: The rat model of chronic renal insufficiency was made by feeding 0.75% adenine forage. The blood biochemical indexes, ion concentration in serum of rat was measured and the pathological changes of rat kidney were observed. Results: Shenduqing Granules obviously increased thymus index (TI). The weight of rat kidney in the treatment group was lighter than that of the model group. The kidney histomorphological study showed that Shenduqing Granules obvionsly reduce the pathological changes. The drug crystals were also reduced. Conclusion: Shenduqing Granules has the potential protection against chronic renal insufficiency in rats. |
| Keywords: | Shenduqing Granules chronic renal insufficiency creatinine blood urea nitrogen calcium glomerulus |
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