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Larvicidal activity of lipophilic extract of Hypericum carinatum (Clusiaceae) against Aedes aegypti (Diptera: Culicidae) and benzophenones determination |
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| Authors: | Flavia Corvello da Silva Francisco Maikon Corrêa de Barros Josiane Somariva Prophiro Onilda Santos da Silva Thiago Nunes Pereira Sérgio A de Loreto Bordignon Vera Lucia Eifler-Lima Gilsane Lino von Poser |
| Institution: | 1. Programa de Pós-Gradua??o em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Rio Grande do Sul, Brazil 2. Laboratório de Imunoparasitologia, Universidade do Sul de Santa Catarina, Av. José Acácio Moreira 787, 88704-900, Tubar?o, Santa Catarina, Brazil 3. Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, 90050-170, Porto Alegre, Rio Grande do Sul, Brazil 4. Centro Universitário La Salle, Coordena??o de Pós-Gradua??o Stricto Sensu e Pesquisa, Av. Victor Barreto 2288, 92010-000, Canoas, Rio Grande do Sul, Brazil |
| Abstract: | In this study, the larvicidal activity of an enriched fraction of the major lipophilic phenolic compounds from Hypericum carinatum Griseb. (Clusiaceae) was investigated against larvae of Aedes aegypti (Diptera: Culicidae), the main vector of dengue virus in Brazil. The larval mortality rate ranged 37.33 to 72.00 % at concentrations of 66–200 μg/mL. The effect demonstrated to be dose-dependent. The lethal concentration 50 % and confidence interval were 100 and 88–111 μg/mL, respectively. The results could be attributed to the presence of cariphenone A and cariphenone B in concentrations of 1.24?±?0.04 and 0.56?±?0.01 %, respectively, determined by high-performance liquid chromatography. Besides, the results reinforce the potential of genus Hypericum as source of alternative insecticides. |
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