肝细胞微环境:抗肝纤维化药物的新靶点

本文以肝星状细胞为切入点，分析了肝细胞微环境与肝纤维化的关系。肝细胞微环境由肝星状细胞、细胞外基质、基质金属蛋白酶、枯否细胞、自然杀伤细胞等共同构成，而肝纤维化是由其相互作用的失衡所致。因此提出，应将肝细胞微环境作为治疗肝纤维化的复合靶点并应用于传统民族药物筛选，以充分发挥民族药物多机制、多靶点的优势，研制抗肝纤维化的创新药物。

Hepatic cellular microenvironment: a novel drug target for anti-hepatic fibrosis

To screen anti-hepatic fibrosis drugs, the relationship between hepatocellular microenvironment and hepatic fibrosis is analyzed and focused on hepatic stellate cells in this paper. Hepatocellular microenvironment is composed of hepatic stellate cells, extracellular matrix, matrix metalloproteinases, Kupffer cells and natural killer cells. Hepatic fibrosis is induced by the imbalance among the parts of hepatocellular microenvironment. So hepatocellular microenvironment should be a complex drug target for the treatment of hepatic fibrosis, and be applied to screen tranditional ethno drugs, which has the advantages of multi target and multi-mechanism on diseases, to develop innovative anti-fibrotic drugs.