| 重型病毒性肝炎经输血传播病毒感染状况调查及其临床意义 |
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| 引用本文： | 舒波,李颖,刘沛.重型病毒性肝炎经输血传播病毒感染状况调查及其临床意义[J].中国医科大学学报,2000,29(2):133-134. |
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| 作者姓名： | 舒波 李颖 刘沛 |
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| 作者单位： | 中国医科大学第二临床学院传染病科!沈阳110003(舒波，李颖，刘沛，王兆荃)，沈阳242医院(马殿玉) |
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| 摘 要： | 目的：调查重型病毒性肝炎经输血传播病毒的感染状况。方法：设计ＴＴＶ基因的特异性引物，采用巢式ＰＣＲ法对３７例重型肝炎进行血清中ＴＴＶ ＤＮＡ的检测，并对ＴＴＶ ＤＮＡ阳性病例进行临床资料分析。结果：３７例重型肝炎中９例血清ＴＴＶ ＤＮＡ阳性（２４．３％），其中７例重叠感染ＨＢＶ，１例重叠感染ＨＣＶ，１例为单纯ＴＴＶ感染，９例中急性重型肝炎，亚急性重型肝炎１例，亚急性重型肝炎６例，慢性重型肝炎２例；
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| 关 键 词： | 重型病毒性肝炎 聚合酶链反应 TTV感染 |
Detection of Transfusion Transmitted Virus Infection and Clinical Investigation Among Patients with Fulminant Hepatitis |
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| Shu Bo,Li Ying,Liu Pei,Ma Dianyu,Wang Zhaoquan.Detection of Transfusion Transmitted Virus Infection and Clinical Investigation Among Patients with Fulminant Hepatitis[J].Journal of China Medical University,2000,29(2):133-134. |
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| Authors: | Shu Bo Li Ying Liu Pei Ma Dianyu Wang Zhaoquan |
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| Abstract: | Objective: To investigate the presence of transfusion transmitted virus (TTV) infection among patients with fulminant hepatitis. Methods: Total of 37 serum samples from patients with fulminant hepatitis were detected for TTV DNA by nested PCR methods. Results: The positive rate of TTV infection among patients with fulminant hepatitis was 24.3% (9/37). Among nine TTV DNA positive patients, seven were coinfected with HBV, one was coinfected with HCV, one was only TTV infection. Conclussion: TTV infection is associated with fulminant hepatitis, only TTV infection and coinfection with other hepatitis virus would be the important cause of fulminant hepatitis and hepatic failure. |
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| Keywords: | transfusion transmitted virus fulminant hepatitis PCR method |
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