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Osteopontin Expression is an Independent Adverse Prognostic Factor in Resectable Gastrointestinal Stromal Tumor and its Interaction with CD44 Promotes Tumor Proliferation |
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| Authors: | Kai-Hsi Hsu Hung-Wen Tsai Pin-Wen Lin Yun-Shang Hsu Yan-Shen Shan Pei-Jung Lu |
| Affiliation: | (1) Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC;(2) Department of Surgery, Tainan Hospital, Department of Health, Executive Yuan, Tainan, Taiwan, ROC;(3) Department of Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC;(4) Department of Surgery, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC;(5) Department of Biotechnology, Southern Taiwan University of Technology, Tainan, Taiwan, ROC;(6) Institute of Clinical Medicine and Department of Surgery, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC |
| Abstract: | BackgroundOsteopontin (OPN) is a multifunctional secreted glycophosphoprotein involved in miscellaneous physiologic and pathologic processes and is functionally related to the transmembrane receptor CD44. Although OPN expression has been identified to be associated with poor prognosis in several gastrointestinal malignancies, its expression in gastrointestinal stromal tumor (GIST) has not been thoroughly investigated. This study was designed to evaluate the clinicopathologic significance of OPN expression in patients with resectable GIST. |
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