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The Decrease of Serum Levels of Human Neutrophil Alpha-Defensins Parallels with the Surgery-Induced Amelioration of NASH in Obesity |
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| Authors: | Melania Manco José Manuel Fernandez-Real Fabio Maria Vecchio Valerio Vellone José María Moreno Vincenzo Tondolo GianFranco Bottazzo Giuseppe Nanni Geltrude Mingrone |
| Affiliation: | 1.Scientific Directorate,Bambino Gesù Hospital and Research Institute,Rome,Italy;2.Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona,Intitut d’Investigació Biomèdica de Girona (IDibGi) and CIBEROBN Fisiopatología de la Obesidad y Nutrición,Girona,Spain;3.Department of Pathology,Catholic University,Rome,Italy;4.Department of Surgery,Catholic University,Rome,Italy;5.Department of Internal Medicine,Catholic University,Rome,Italy |
| Abstract: | BackgroundInnate immune system participates actively into inflammatory processes, with immune cells and liver secreting a number of immune peptides. Among them, both soluble CD14 receptor (sCD14) and human neutrophil alpha-defensins (HNDs) may represent serum markers of necro-inflammation in obese patients with non-alcoholic fatty liver disease. |
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