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Factors Predicting Outcome of Total Thyroidectomy in Young Patients with Multiple Endocrine Neoplasia Type 2: A Nationwide Long-Term Follow-up Study
Authors:Jennifer M. J. Schreinemakers  Menno R. Vriens  Gerlof D. Valk  Jan-Willem B. de Groot  John T. Plukker  Klaas M. A. Bax  Jaap F. Hamming  Rob B. van der Luijt  Daniel C. Aronson  Inne H. M. Borel Rinkes
Affiliation:(1) Department of Surgery, University Medical Center Utrecht, Hpnr. G04.228, Heidelberglaan 100, 3584CX Utrecht, The Netherlands;(2) Pediatric Surgical Center of Amsterdam, Emma Children’s Hospital AMC, Academic Medical Center and VU Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands;(3) Department of Endocrinology, University Medical Center Utrecht, Hpnr. G04.228, Heidelberglaan 100, 3584CX Utrecht, The Netherlands;(4) Department of Endocrinology, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands;(5) Department of Surgery, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands;(6) Department of Pediatric Surgery, Erasmus Medical Center Rotterdam, P.O. Box 2060, 3000CB Rotterdam, The Netherlands;(7) Department of Surgery, Leiden University Medical Center, P.O. Box 9600, 2300RC Leiden, The Netherlands;(8) Department of Medical Genetics, University Medical Center Utrecht, Hpnr. G04.228, Heidelberglaan 100, 3584CX Utrecht, The Netherlands;(9) Present address: Department of Surgery/Pediatric Surgery, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500HB Nijmegen, The Netherlands
Abstract:

Background  

Multiple endocrine neoplasia type 2 (MEN 2) is caused by a RET mutation in chromosome 10. All MEN 2 patients develop medullary thyroid carcinoma (MTC). The age-related risk of MTC is associated with the type of RET mutation. Our aim was to identify prognostic factors associated with recurrent MTC in MEN 2 patients.
Keywords:
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