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Minimally invasive colon resection for malignant colonic conditions is associated with a transient early increase in plasma sVEGFR1 and a decrease in sVEGFR2 levels after surgery |
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| Authors: | H M C Shantha Kumara J C Cabot A Hoffman M Luchtefeld M F Kalady N Hyman D Feingold R Baxter R L Whelan |
| Institution: | (1) Section of Colon and Rectal Surgery, Department of Surgery, New York-Presbyterian Hospital-Columbia Campus, 177 Fort Washington Avenue, New York, NY 10032, USA;(2) Division of Colon and Rectal Surgery, Ferguson Clinic, 4100, Lake Dr. SE, Suite 205, Grand Rapids, MI 49546, USA;(3) Department of Colorectal Surgery, Cleveland Clinic, 9500, Euclid Avenue, A30, Cleveland, OH 44195, USA;(4) Department of Surgery, Fletcher 465, University of Vermont, College of Medicine, Burlington, VT 05401, USA |
| Abstract: | IntroductionPlasma VEGF levels increase after minimally invasive colorectal resection (MICR) and remain elevated for 2–4 weeks. VEGF induces physiologic and pathologic angiogenesis by binding to endothelial cell (EC) bound VEGF-Receptor-1 (VEGFR1) and VEGFR2. Soluble forms of these receptors sequester plasma VEGF, decreasing the amount available to bind to EC-bound receptors. Ramifications of surgery-related plasma VEGF changes partially depend on plasma levels of sVEGFR1 and sVEGFR2. This study assessed perioperative sVEGFR1 and sVEGFR2 levels after MICR in patients with colorectal cancer. |
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