BRCA2 N372H polymorphism and breast cancer susceptibility: a meta-analysis involving 44,903 subjects |
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| Authors: | Li-Xin Qiu Lei Yao Kai Xue Jian Zhang Chen Mao Bo Chen Ping Zhan Hui Yuan Xi-Chun Hu |
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| Institution: | (1) Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China;(2) Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;(3) State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China;(4) Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China;(5) Department of Geriatrics, First Affiliated Hospital, Nanjing Medical University, Nanjing, China;(6) Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China;(7) Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, China; |
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| Abstract: | Published data on the association between BRCA2 N372H polymorphism and breast cancer risk are inconclusive. To derive a more
precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength
of association between them. A total of 22 studies including 22,515 cases and 22,388 controls were involved in this meta-analysis.
Overall, no significant associations were found between BRCA2 N372H polymorphism and breast cancer risk when all studies pooled
into the meta-analysis (NH versus NN: OR = 1.01, 95% CI = 0.97–1.05; HH versus NN: OR = 1.05, 95% CI = 0.97–1.13; dominant
model: OR = 1.01, 95% CI = 0.98–1.05; and recessive model: OR = 1.05, 95% CI = 0.98–1.13). In the subgroup analysis by ethnicity,
still no significant associations were found for Caucasians, Asians, or Africans. When stratified by study design, statistically
significantly elevated risk was found for 372H allele based on population-based studies (HH versus NN: OR = 1.11, 95% CI = 1.01–1.21;
dominant model: OR = 1.05, 95% CI = 1.00–1.10; recessive model: OR = 1.09, 95% CI = 1.00–1.18). In conclusion, this meta-analysis
suggests that the BRCA2 372H allele may be a low-penetrant risk factor for developing breast cancer. However, large sample
and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted
to confirm this finding. |
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