绝经后高血压研究进展

绝经后高血压是指女性在生理性绝经1年以后出现的血压升高,由于激素水平等其他方面的影响,常伴有肥胖、血脂异常、糖代谢异常和胰岛素水平增高,以及交感神经兴奋性增高等。由于其已成为冠心病(CHD)的危险因素之一,因此愈来愈受到人们的关注。绝经后女性血压升高的机制复杂且是多因素的,包括雌激素减少、垂体激素过多、体重增加,以及综合因素和其他未知神经体液因素的影响。鉴于绝经后女性症状的多样性,治疗高血压时,在降压药物的选用上需考虑患者的具体病症,因人而异。关于应用激素替代疗法(HRT)的机制已有多项实验研究证实,但对于患有高血压的绝经后妇女的疗效证据尚不确切。目前能确定的是,高血压不是应用HRT的禁忌证。而是否一些患有CHD的妇女可从HRT治疗中获益,仍需等待更前沿的随机临床实验结果。

Advance in Research on Post-menopause Hypertension (review)

Post-menopause hypertension in female is the appearance of elevation of blood pressure in one year after menopause.It will always bring obesity,blood lipid abnormality,disorders of carbohydrate metabolism,elevation of insulin's leave,elevation of sympathetic nerve's irritability,and so on by the hormone leave and other reason,which has caused wide public concern as one of the reason of coronary heart disease(CHD).The possible pathogenesis of female hypertension is complicated and many factors.These disorders may include decrease of estrogen,overfull pituitrin,putting on weight,composite factors and others unknown neurohumoral factors.During the treatment of high blood pressure,considering the diversity of post-menopause female,it need take concrete illness into account to choose reducing the pressure drug.There are many experiments to approve applied hormone replacement therapy(CRT),but it is still incertitude on post-menopause hypertensive female sufferer.At the same time,hypertension is not the contraindication in application of HRT.It need more advanced stochastic clinical experimentation to prove whether CHD female could benefit from HRT application.