老年人口腔颌面部肉瘤33例临床分析

目的：探讨老年人口腔颌面部肉瘤的临床特点及预后。方法：收集2000—2009年治疗的33例老年人（〉60岁）口腔颌面部肉瘤病例进行回顾性分析。利用SPSS12.0软件包进行统计学分析,预后影响因素采用χ2检验。根据随访资料,采用乘积极限法统计生存率。结果：33例患者中,男23例,女10例。平均年龄71岁（61～88岁）,平均随访时间21个月（3～83个月）。随访患者29例,失访患者4例,随访率为87.88%。随访患者中,原发病例20例,因肉瘤复发就诊（复发病例）9例。随访病例均经手术治疗,其中单纯手术治疗12例,术后辅助放疗9例,术后辅助放化疗8例。经χ2检验,单纯手术治疗组和术后辅助放化疗组对预后有显著影响（P〈0.05）。原发病例中,术后局部复发11例,复发率55%。复发病例中,7例术后出现复发,2例出现远处转移。随访病例中,1年生存率为69%,3年生存率为40.8%,5年生存率为25.4%。单纯手术治疗组和术后联合放化疗组的生存函数采用Logrank检验进行比较,差异具有显著性。结论：手术是治疗老年人口腔颌面部肉瘤的主要手段。根治性手术联合术后放化疗对改善老年肉瘤患者的预后可能有益。

Sarcoma of the elderly in oral and maxillofacial region:Clinical analysis of 33 consecutive patients

PURPOSE: To report outcome on patients over 60 years of age with sarcoma in oral and maxillofacial region,with respect to clinical behaviors,treatment and prognosis.METHODS: Retrospective analysis of patients over 60 years of age with histologically proven oral and maxillofacial sarcomas treated in Dept.of Oral and Maxillofacial Surgery,Ninth people' s Hospital,Shanghai Jiao Tong University School of Medicine,from 2000 to 2009 were performed.Differences between groups were assessed using Chi-squared test.Ov...