高渗物质置豚鼠圆窗对内耳电生理和病理形态影响

用７１只豚鼠，耳后进路暴霜圆窗，置入ＮａＣ１或ＫＣ１或蔗糖晶体，测试不同时间组动物的耳蜗神经动作电位（ＡＰ），并观察内耳的形态学改变。结果：置ＮａＣ１或ＫＣ１后，ＡＰ阈值明显提高，潜伏期延长，但随时间延长，ＡＰ阈值有所下降；病理学研究发现置ＮａＣ１或ＫＣ１后耳蜗损伤仅局限在１、２周，前庭器也有病理学变化；置蔗糖后无上述情况出现。结果提示；圆窗放置ＮａＣ１和ＫＣ１对内耳的损伤可能与Ｎａ＋或Ｋ＋进入内耳产生的化学迷路炎有关，且其损伤属不可逆性改变。

Effect of osmotic matters in round window on electrophysiology and pathology of inner ear

NaC1 or KC1 or sugar crystals were placed in the round window of 71 guinea pigs.The cochlar nerve action potential was tested in variant time groups and the cochlar pathological change was observed. The results showed that the AP threshold rose and the AP lantency lengthened obviously. But the AP threshold would partly drop because of the lengthening of time.The pathological study showed that NaC1 or KC1 could only injure the basic and the second circle of the cochlea.The saccule and utricle had pathological changes too.However,sugar hadn't any obvious effects on the inner ear.The reasons of the inner ear injury caused by NaC1 or KC1 in the round window were discussed in the paper.