Effect of serotonergic, corticostriatal and kainic acid lesions on the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine (MPTP) in mice |
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Authors: | Eldad Melamed Eli Pikarski Anat Goldberg Jutta Rosenthal Anat Uzzan Nissim Conforti |
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Institution: | 1. Monk Prayogshala, Mumbai, Maharashtra, India;2. University of Connecticut, Storrs, CT, United States |
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Abstract: | In mice, prior destruction of striatal 5-hydroxytryptamine (5-HT) neurons by intrastriatal or intraventricular injections of 5,7-dihydroxytryptamine did not abolish or attenuate DA depletions produced in striatum by 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). This suggests that although they contain monoamine oxidase type B, the oxidative conversion of MPTP to 1-methyl-4-phenyl-pyridinium ion (MPP+) does not take place in 5-HT neurons. Likewise, decortication and kainic acid lesions did not prevent or enhance striatal MPTP-induced DA decrements suggesting that corticostriatal projections and striatal neurons are not involved in the mechanisms of MPTP neurotoxicity. |
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Keywords: | MPTP 1-Methyl-4-phenyl-1 2 5 6-tetrahydropyridine Striatum Mouse Dopamine Serotonergic neuron Decortication Kainic acid lesion |
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