Echocardiographic indices of left ventricular diastolic dysfunction in 647 individuals with preserved left ventricular systolic function |
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Authors: | Pedersen Frants Raymond Ilan Madsen Lene H Mehlsen Jesper Atar Dan Hildebrandt Per |
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Affiliation: | Department of Cardiology and Endocrinology, Frederiksberg University Hospital, Nordre Fasanvej 57, DK-2000 Frederiksberg-Copenhagen, Denmark. frants@dadlnet.dk |
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Abstract: | BACKGROUND: Knowledge about the occurrence of isolated diastolic dysfunction (DD) in the general population is limited. AIMS: This population study was performed to assess the frequency and distribution pattern of echocardiographic indices of left ventricular (LV) DD in an elderly population aged 50-89 years in which LV systolic function is preserved. METHODS AND RESULTS: The study population (n=764) recruited from the background population answered a heart failure questionnaire and underwent echocardiography. Excluding subjects with a LV ejection fraction <50% or atrial fibrillation, diastolic function was evaluated in 647 subjects. The frequency of impaired relaxation according to earlier guidelines was 0.5%, vs. 2.5% using age- and gender-specific normal values of 'E/A-ratio' and 'deceleration time'. In a subpopulation of 167 participants, 6.6% had 'pseudonormalisation'. No difference was found in the frequency of dyspnea in subjects with impaired relaxation or 'pseudonormalisation' compared to subjects with normal filling pattern. CONCLUSION: The prevalence of LV impaired relaxation was highly dependent on the choice of normal (cut-off) values for Doppler indices. Furthermore, our findings suggest that either isolated DD is often asymptomatic, or that Doppler flow derived parameters as a diagnostic method for assessing DD have a low specificity when used as a screening tool in the general population. |
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Keywords: | Diastolic dysfunction Heart failure Echocardiography Epidemiology |
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