RNA Metabolism in Lymphocytes Stimulated by Phytohemagglutinin: Initial Responses to Phytohemagglutinin |
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| Authors: | COOPER, HERBERT L. RUBIN, ARNOLD D. |
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| Affiliation: | 1 Human Genetics Branch, National Institute of Dental Research, NationalInstitutes of Health, Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland.
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| Abstract: | The initial changes in lymphocyte RNA metabolism produced by treatmentwith phytohemogglutinin (PHA) are described. The earliest change was adecrease in total RNA (i-RNA), detectable after 30 minutes of exposure toPHA. This loss could not be localized to any of the major types of cellularRNA. After 1 hour, accelerated synthesis of RNA, shown by incorporation ofu-H3, was detected, and a progressive increase in rate of synthesis continuedfor 24 hours.The significance of the early loss of RNA as related to the onset of lymphocyte growth is discussed. Submitted on August 7, 1964 Accepted on October 26, 1964 |
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