缬沙坦对压力超负荷下心脏多聚二磷酸腺苷核糖合成酶活性的影响

目的:观察缬沙坦对慢性压力超负荷下左心室心肌多聚二磷酸腺苷(ADP)核糖合成酶(PARP)活性、心脏形态及心功能的影响.方法:Wistar雄性大鼠34只随机分为假手术组(sham组)10只、腹主动脉缩窄组(AC组)12只、腹主动脉缩窄加缬沙坦干预结扎组(Val组)12只.术后24周行心脏超声和血流动力学检查,并取左心室心肌检测PARP活性.结果:与sham组比较,AC组PARP活性显著增强(P＜0.01),左心室质量/体重(LVW/BW)显著升高(P＜o.05),左心室射血分数显著降低(P＜o.05);与AC组比较,Val组PARP活性显著减弱(P＜0.01),LVW/BW显著降低(P＜0.05),左心室射血分数明显升高(P＜0.05).结论:缬沙坦可抑制压力负荷下心室肌PARP过度激活,并减轻心室重构及心功能的损害.

Effect of valsartan on action of poly(ADP-ribose) polymerase in pressure overload myocardium

Objective:To study the effect of valsartan on PARP activition and myocardial remodeling in the left ventricle of the rat undergoing chronic pressure overload.Method:Thirty rats were randomly divided into 3 groups,as the sham operation group sham group,(n=10),the abdominal aorta constriction group(AC group,n=12),and the AC valsartan group(Val group,n=12).Transthoracic echocardiography and homodynamic were performed.PARP activity of the model rats was detected.Result:Compared with the sham group,PARP activity and LVW/BW increased significantly in the AC group(P<0.05).Compared with the AC group,PARP activity and LVW/BW were decreased while ejection fraction of left ventricular increased significantly in the Val group(P<0.05).Conclusion:Valsartan could inhibit abnormal PARP activation and ventricular remodeling in rat undergoing chronic pressure overload.