苦参碱对肝癌化疗乙肝病毒活动状态的影响

目的:研究肝癌化疗对乙肝活动状态的影响及苦参碱的作用。方法:检测89例肝癌患者的血清乙型肝炎病毒标记物及其HBV DNA定量,分为两组,均采用GP方案(吉西他滨+顺铂)化疗,单纯化疗者42例,联合苦参碱者47例,化疗期间、化疗后8周监测HBV DNA及标志物、肝功能。结果:化疗后HBV DNA量较化疗前增加(P<0.01),乙肝病毒再激活与肝炎活动相关,联用苦参碱可减轻肝功能损害,与单纯化疗组相比,差异有显著性,但对降低血清HBVDNA载量作用不明显。结论:肝癌化疗可引起乙肝病毒再激活,并导致肝炎活动,苦参碱能保护肝细胞,改善肝功能,对乙肝病毒再激活引起的肝损害有保护作用,但抗病毒作用不明显。

Matrine Therapy for the Hepatitis B Virus Replication Status in Hepatitis Bs -Antigen Seropositive Hepatocellular Carcinoma Patients Undergoing Cytotoxic Chemotherapy

Objective:To study the Hepatitis B virus replication status in patients undergoing chemotherapy with hepatocellular carcinoma and the interfering effect of Matrine.Methods:89 HBsAg-positive patients with inoperable hepatocellular carcinoma underwent systemic chemotherapy.2 group were compared in the randomized study.42 patients only received combination gemcitabine and cisplatin(GP).The other 47 patients used GP combined with Matrine therapy.The serum HBV DNA quantities,HBV signs and liver function were tested during and for 8 weeks after chemotherapy.Results:The HBV DNA quantities increased post chemotherapy(P<0.01).The hepatitis activation correlated with increasing of HBV quantities.The therapy of GP combined with Matrine can alleviate the liver injury,but have no marked effect to decrease HBV quantities.Conclusion:The chemotherapy in hepatocellular carcinoma can induce increasing of HBV quantities and activation of hepatitis.Matrine can protect the liver cells and improve liver function,but have no marked effect to inhibit HBV.