IL-8及其受体CXCR1在子宫内膜异位症中的表达及意义

目的探讨白细胞介素8(IL-8)及其受体CXCR1在子宫内膜异位症(EMT)内膜上的表达水平及其在EMT发病中的意义。方法 EMT患者38例作为研究组,非内膜异位症(非内异症)患者29例作为对照组。免疫组化法检测EMT患者异位内膜、在位内膜及非内异症的对照子宫内膜之间IL-8与CXCR1的表达情况。结果所有异位内膜均可检测到IL-8与CXCR1蛋白的表达,且其染色强度高于在位内膜及正常生育期子宫内膜(P0.05),EMT患者的在位内膜IL-8与CXCR1的表达高于同期正常生育期子宫内膜(P0.05),对照组和异位组增生期子宫内膜与分泌期子宫内膜相比IL-8与CXCR1的表达无显著性差异(P0.05)。结论证明IL-8在正常生育期子宫内膜、EMT患者在位子宫内膜及异位灶组织的表达差异与CXCR1一致,CXCR1/IL-8蛋白的异常表达可能在内异症的发生中发挥着极为重要的作用。

Expression of Interleukin-8 and CXCR1 in Endometriosis and Its Significance

Objective To study the expression of interleukin-8（IL-8） and CXCR1 in endometriosis. Methods Thirty-eight cases of endometriosis were selected as study group,and 29 cases of non- endometriosis served as control group. Immunohistochemistry was used to detect the expression of IL-8 and CXCR1 in the eutopic and ectopic endometrium in endometrium（study group） and in non- endometrium （control group）. Results The IL-8 and CXCR1 protein expression was detected in ectopic endometrium. The staining intensity of CXCR1 and IL-8 in endometrium was higher than that in eutopic endometrium and normal endometrium（P〈0.05）. The expression of CXCR1 and IL-8 had no difference in proliferative phase and secretory phase between the ectopic group and the control group（P〉0.05）. Conclusion The abnormal expression of IL-8 is in accordance with CXCR1 ,and the abnormal expression of IL-8/CXCR1 may be play a very important role in pathogenesis of endometriosis.