| 急性白血病患者血浆和脑脊液中可溶性L—选择素测定及意义 |
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| 引用本文： | 常建华,徐敏.急性白血病患者血浆和脑脊液中可溶性L—选择素测定及意义[J].湖南医科大学学报,2002,27(2):151-153. |
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| 作者姓名： | 常建华 徐敏 |
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| 作者单位： | [1]中南大学湘雅医院血液科，长沙410008 [2]中南大学湘雅二医院血液科，长沙410011 |
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| 摘 要： | 目的：探讨急性白血病血浆及脑脊液可溶性L－选择素水平（sL-selectin)与急性白血病发病及病情变化的关系。方法：用酶联免疫吸附双抗体夹心法（ELISA）测定40例急性白血病患者的血浆及28例急性淋巴细胞白血病患者的脑脊液中sL-selectin,并分别与正常对照组比较。结果：初治及难治性急性白血病患者体内的sL-selectin水平较缓解者及正常对照者均显著增高（P＜0．001）。且sL-selectin水平与临床过程有关，随着病情缓解和复发，sL-selectin水平也随之变化。结论：监测患者血浆和脑脊液sL-selectin水平对早期诊断急性白血病的复发及脑膜浸润有一定意义。
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| 关 键 词： | 急性白血病 血浆 脑脊液 可溶性L－选择素 测定 |
Clinical significance of the detection of the sL-selectin level in patients with acute leukemia] |
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| Jian-hua Chang,Zhen-hua Qi,Min Xu.Clinical significance of the detection of the sL-selectin level in patients with acute leukemia][J].Bulletin of Hunan Medical University,2002,27(2):151-153. |
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| Authors: | Jian-hua Chang Zhen-hua Qi Min Xu |
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| Institution: | Department of Clinical Haematology, Xiangya Hospital, Central South University, Changsha 410008, China. |
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| Abstract: | OBJECTIVE: To study the relationship between the episode and state of acute leukemia and the level of soluble L-selectin (sL-selectin) in the plasma and cerebrospinal fluid. METHODS: With a sandwich enzyme-linked immunosorbent assay (ELISA), the levels of sL-selectin in the plasma of 40 patients with acute leukemia and in the cerebrospinal fluid of 28 patients with acute lymphoblastic leukemia were measured, and compared with 20 controls. RESULTS: The levels of sL-selectin were significantly higher in the patients with untreated and therapy-resistant acute leukemia or leukemia relapse than those in the complete remission patients and the controls (P < 0.001). The levels of SL-selectin were related to the clinical course of acute leukemia. CONCLUSION: Monitoring the sL-selectin level may be useful for evaluating leukemia activity, in particular for the detection of leukemia relapse and meningeal infiltration. |
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