乙型肝炎患者自身混合淋巴细胞反应的探讨

本文建立了细胞自身免疫识别和相互作用的体外模型－自身混合淋巴细胞反应（ＡＭＬＲ）的实验方法，并对１０２例ＨＢＶ感染者非Ｔ－Ｔ细胞间ＡＭＬＲ进行了研究。结果表明，不同临床类型的乙肝患者ＡＭＬＲ均有不同程度的缺陷，且ＡＭＬＲ缺陷与血清ＨＢＶ复制也存在相关性。ＡＭＬＲ缺陷与刺激细胞相关与反应性Ｔ细胞无关；在刺激细胞对ＡＭＬＲ的诱导中，ＤＲ抗原起主要作用，ＤＱ抗原也有一定的作用；乙型肝炎患者刺激细胞表面Ｄ

The study of autologous mixed lymphocyte reaction in patients with hepatitis B

The autologous mixed lymphocyte reaction(AMLR)is thought to represent the self regula-tion and interaction between T and non-T cells,and play an important role in immune surveil-lance and resistancce to viral infection.This paper established the method of AMLR and investi-gated the changes of AMLR in 102 patients with HBV infection of different clinical types.Theresults showed that all patients except that HBsAg positive carriers and chronic persistent hep-atitis B had unchanged AMLR demonstrated impaired AMLR.Among them AMLR was foundsignificantly decreased in patients with severe viral hepatitis B and cirrhosis,next in patients withchronic active hepatitis B,then in patients with acute hepatitis B.It was suggested that theAMLR relate to the clinical types.Also we discovered that AMLR was associated with serologicevidance of actival HBV replication.Further study showed that the impaired value for theAMLR corrlated with the stimulators dysfunction,but not the defect of the AMLR correlatedwith the stimulators dysfunction,but not the defect of responders.AMLR was indueced greatlyby DR antigen,partly by DQ antigen.Induction of DR antigen and DQ antigen on the stimula-tors in patients with hepatitis B for AMLR was obviously low compared to normal invididual.Itreflect dysfunction for intercellular recognition,and may contribute to the impaired regulation ofimmune function in the mechanism of hepatitis B.