不同鼠龄和学习记忆成绩大鼠海马锥体细胞自发放电差异性研究

目的 结合非线性理论初步探讨不同鼠龄和学习记忆成绩大鼠海马锥体细胞（PC）和自发放电特征，方法 将实验大鼠按鼠龄和学习记忆成绩分组。年龄组分老年组（16－19月）和青年组（3－4月）；学习记忆组分成绩好，差组，进行在体单电极细胞外记录。结果 海马锥体细胞自发放电序列峰峰间隔（ISI）分布图在各组均无明显规律；老年组锥体发放电ISI复杂度（C）小于年轻组，成绩差组小于成绩好组（P＜0．05），老年组三联优势模式百分比（PF）明显低于年轻组（P＜0．01），成绩差组低于成绩好组（P＜0．05）。结论 神经元ISI复杂度和优势模式百分比与年龄，记忆能力有一定相关性，提示对神经元复杂度与优势模式的分析有助于揭示神经元自发放电的信息编码特征。

Differences of spontaneous discharges of hippocampal pyramidal cells in rats of different age and memory groups

Objective To investigate the characteristics of spontaneous discharges of hippocampal pyramidal cells (PC) in rats in age and memory groups with the help of nonlinear theory. Methods Rats were randomly divided into age group and memory group. Age group included aged group (16-19 months) and young group (3-4 months) whereas memory group included good memory and poor memory groups in adult. Extracellular single cell recording was performed in vivo . Results No characteristics of the rhythm of spontaneous discharges of hippocampal pyramidal cells in distribution figure of interspike interval(ISI) were found, but the loss of complexity(C) and low percentage of favored patterns(PF) were found in age and poor memory groups. Conclusion The ISI complexity and the PF of the hippocampal pyramidal cells are correlated to age and memory, suggesting that the analysis of the complexity and favored patterns may be helpful for the discovery of the characteristics of the information coding in spontaneous discharges of hippocampal pyramidal cells.