海洛因依赖者应激相关因素及血清可溶性Fas和Fas配体水平的变化

目的:探讨海洛因依赖者应激相关因素的变化以及与血清可溶性Fas和Fas配体水平的关系及其意义。方法:采用知觉心理压力量表、中文健康问卷、特质应对方式问卷、领悟社会支持量表对自愿戒毒的海洛因依赖者40例施测,并检测其血清中可溶性Fas和Fas配体水平,与39例健康人群作对照及相关研究。结果:海洛因依赖组的知觉心理压力、中文健康问卷、消极应对得分及血清Fas配体水平高于健康对照组(P<0.01或P<0.05),而积极应对、领悟社会支持量表得分低于健康对照组(P<0.01),血清可溶性Fas水平与对照组比较无统计学差异(P>0.05)。两组分别做相关分析显示,海洛因依赖组血清Fas配体水平和积极应对方式成负相关,对照组血清Fas配体与应激相关因素之间没有相关性。结论:海洛因依赖者在心理应激有关因素方面大多差于健康人群,并且血中Fas配体水平异常升高,提示海洛因依赖增加了Fas介导的细胞凋亡,可以解释海洛因依赖者免疫受损的原因。应激相关因素中的应对方式能影响海洛因依赖者血清Fas配体水平。

The changes of stress-related factors and fas system in heroin addicts

Objective: To investigate the changes of stress-related factors, sFas, FasL level in peripheral serum of heroin addicts. Methods: CPSS, CHQ-12, PC, NC and PSSS were used for 40 heroin addicts as well as 39 normal controls include concentrations of sFas and FasL were measured in two groups. The scores and the concentrations were compared with the normal control and the correlations were studied respectively. Results: The scores of CPSS, CHQ-12, NC and the concentrations of serum FasL in heroin addicts were higher than that of the controls(P<0.01 or P<0.05). The scores of PC and PSSS in heroin addicts were lower than that of the controls(P<0.01). There was no significant difference of the serum sFas level between heroin addicts and controls(P>0.05). The correlation analysis show there is nagetive correlation between serum FasL and active coping style in heroin addicts. Otherwise there is no correlation in the controls. Conclusion: The stress-related fators in heroin addicts were worse than that in healthy controls and there was an abnormally higher serum level of FasL in heroin addicts. It is suggested that heroin produces an increase in the Fas-mediated apoptosis and it might explain the decreased immunity function in heroin addicts. The coping style among stress-related factors might influnce the level of FasL in heroin addicts.