| 血清MCP-1水平与MCP-1-2518G/A多态性和急性心肌梗死的相关性 |
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| 引用本文： | 姜九,何国平,师干伟,许联红,戚传平. 血清MCP-1水平与MCP-1-2518G/A多态性和急性心肌梗死的相关性[J]. 江苏大学学报(医学版), 2011, 21(3): 249-254 |
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| 作者姓名： | 姜九 何国平 师干伟 许联红 戚传平 |
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| 作者单位： | 1. 江苏大学附属武进医院,心血管内科,江苏,常州,213002
2. 江苏大学附属武进医院,中心实验室,江苏,常州,213002 |
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| 基金项目： | 江苏大学临床医学科技发展基金资助项目 |
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| 摘 要： | 目的:探索中国苏南地区汉族人群血清单核细胞趋化蛋白(MCP)-1水平与该蛋白基因 -2518G/A多态性和急性心肌梗死(AMI)的相关性.方法:对94例AMI患者(AMI组)和73例经冠脉造影检查证实非冠心病者(对照组)采用PCR-RFLP法检测MCP-1 -2518G/A多态性,采用ELISA法检测血清MCP-1水平...
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| 关 键 词： | 单核细胞趋化蛋白-1 基因多态性 急性心肌梗死 |
Association of the serum MCP-1 concentration with MCP-1 -2518 G/A polymorphism and acute myocardial infarction |
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| JIANG Jiu,HE Guo-ping,SHI Gan-wei,XU Lian-hong,QI Chuan-ping. Association of the serum MCP-1 concentration with MCP-1 -2518 G/A polymorphism and acute myocardial infarction[J]. Journal of Jiangsu University Medicine Edition, 2011, 21(3): 249-254 |
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| Authors: | JIANG Jiu HE Guo-ping SHI Gan-wei XU Lian-hong QI Chuan-ping |
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| Affiliation: | JIANG Jiu1,HE Guo-ping1,SHI Gan-wei1,XU Lian-hong2,QI Chuan-ping2(1.Department of Cardiology,2.Central Laboratory,Affiliated Wujin Hospital of Jiangsu University,Changzhou Jiangsu 213002,China) |
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| Abstract: | Objective: To investigate the association of MCP-1 serum level with MCP-1 gene-2518 G/A polymorphism and acute myocardial infarction(AMI) in Chinese Han population of Sunan region.Methods: The MCP-1-2518 G/A polymorphism was genotyped and its serum concentration was measured in 94 patients with AMI and 73 control subjects by PCR-RFLP and ELISA,respectively.Results: Serum MCP-1 level(M/IQR) in AMI group was significantly higher than that in control group(186.24/285.15 pg/ml vs 100.71/134.02 pg/ml,P=0.001).No... |
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| Keywords: | monocyte chemoattractant protein-1 genetic polymorphism acute myocardial infarction |
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