| 海洋生物活性药物BA-TPQ和FBA-TPQ对胃癌细胞的作用 |
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| 引用本文： | 徐哲,张徐,钱茜,孙靖,钱晖,朱伟,许文荣. 海洋生物活性药物BA-TPQ和FBA-TPQ对胃癌细胞的作用[J]. 江苏大学学报(医学版), 2011, 21(3): 220-223,228 |
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| 作者姓名： | 徐哲 张徐 钱茜 孙靖 钱晖 朱伟 许文荣 |
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| 作者单位： | 江苏大学基础医学与医学技术学院,江苏,镇江,212013 |
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| 基金项目： | 国家自然科学基金资助项目，江苏大学科技创新团队和拔尖人才项目 |
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| 摘 要： | 目的:观察两种海洋生物活性药物BA-TPQ和FBA-TPQ对人胃癌细胞株BGC-823的作用与机制.方法:采用四唑氮蓝(MTT) 法测定不同浓度BA-TPQ和FBA-TPQ对BGC-823细胞的生长作用,应用流式细胞术检测BA-TPQ和FBA-TPQ对 BGC-823细胞增殖和细胞周期的影响,应用蛋白质印迹法检测BA-...
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| 关 键 词： | 海洋生物活性药物 胃癌 胃癌细胞系 细胞凋亡 |
Mechanism and anticancer activity of makaluvamine analogues BA-TPQ and FBA-TPQ on gastric cancer cells |
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| XU Zhe,ZHANG Xu,QIAN Qian,SUN Jing,QIAN Hui,ZHU Wei,XU Wen-rong. Mechanism and anticancer activity of makaluvamine analogues BA-TPQ and FBA-TPQ on gastric cancer cells[J]. Journal of Jiangsu University Medicine Edition, 2011, 21(3): 220-223,228 |
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| Authors: | XU Zhe ZHANG Xu QIAN Qian SUN Jing QIAN Hui ZHU Wei XU Wen-rong |
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| Affiliation: | XU Zhe,ZHANG Xu,QIAN Qian,SUN Jing,QIAN Hui,ZHU Wei,XU Wen-rong(School of Medical Science and Laboratory Medicine,Jiangsu University,Zhenjiang Jiangsu 212013,China) |
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| Abstract: | Objective: To investigate the mechanism and anticancer effect of BA-TPQ and FBA-TPQ on the proliferation of gastric cancer cells(BGC-823) in vitro.Methods: Cell proliferation in different concentration was determined by Methyl thiazolyl tetrazolium(MTT) assay.The fluorescence flow cytometry(FCM) was applied to detect the apoptosis induction and alteration of cell cycle phase.The effect of BA-TPQ and FBA-TPQ on the signaling pathway of BGC-823 cells were detected by Western-blot.Results: After 24 h of treatm... |
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| Keywords: | makaluvamine analogues gastric cancer gastric cancer cells apoptosis |
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