Effects of all-trans retinoic acid on the morphology of human epidermal cells in vitro |
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| Authors: | I. Konohana T. Hashimoto P. J. Dykes R. Marks |
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| Affiliation: | (1) Department of Medicine (Dermatology), University of Wales College of Medicine, CF4 4XN Heath Park, Cardiff, UK |
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| Abstract: | Summary The effects of all-trans retinoic acid on human epidermal cell cultures were studied using ultrastructural techniques. Differentiation and stratification were reduced in retinoic acid treated epidermal cells. Treated cells developed a rounded appearance and seemed to contain more granules and vacuoles than usual. Desmosomes were not found in treated cells. |
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| Keywords: | All-trans retinoic acid Epidermal cells Ultrastructure Differentiation Stratification |
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