PCT、白细胞参数、IL-6和IL-10在早期鉴别上叶肺炎与上叶肺结核中的作用

目的 探讨血清降钙素原（PCT）、白细胞参数、白介素-6（IL-6）和白介素-10（IL-10）在上叶社区获得性肺炎（CAP）与上叶肺结核中表达的差异。方法 选取2015年1月至2015年12月在南通市第六人民医院门诊就诊的上叶CAP患者93例，上叶肺结核患者113例为研究对象。统计其一般情况及PCT、白细胞参数、IL-6、IL-10等相关实验室指标，比较上叶CAP与上叶肺结核在上述实验室参数中的区别。结果 上叶CAP患者发病平均年龄（53.47±15.36）岁，男性占60.2%（56/93）；上叶肺结核患者发病平均年龄（51.73±17.44）岁，男性占57.5%（65/113）。两种疾病中男性相对较多，发病年龄相仿。上叶CAP患者PCT、IL-6和IL-10分别为（0.38±0.08）ng/mL、（25.29±4.29）pg/mL和（0.091±0.005） μg/L,上叶肺结核患者PCT、IL-6和IL-10分别为（0.05±0.01）ng/mL、（10.55±2.71）pg/mL和（0.027±0.002）μg/L，上叶CAP患者高于上叶肺结核患者，差异均有统计学意义（P<0.05）。结论 实验室检查血清中PCT、IL-6和IL-10对早期鉴别诊断上叶CAP和上叶肺结核具有重要的临床指导意义。

The role of PCT,leukocyte parameters,IL-6 and IL-10 in early identification of upper lobe pneumonia and upper lobular pulmonary tuberculosis

Objective To compare the different serum levels of PCT, leukocyte parameters, IL-6 and IL-10 between upper lobe community-acquired pneumonia (CAP) and upper lobe pulmonary tuberculosis. Methods Ninety-three patients with upper lobe CAP and 113 patients with upper lobe pulmonary tuberculosis from January 2015 to December 2015 were enrolled in the outpatient department of the Sixth People's Hospital of Nantong. We retrospectively reviewed the general situation and PCT, leukocyte parameters, IL-6, IL-10 and other related laboratory indicators. The difference between upper lobe CAP and upper lobe pulmonary tuberculosis were compared. Results There were 60.2%（56/93） male patients with upper CAP, and the age of onset was (53.47±15.36) years. The male patients with upper pulmonary tuberculosis were 57.5%（65/113） and the age of onset was (51.73±17.44) years. There were relatively more men in both diseases and the age of onset was similar. The PCT, leukocyte parameters, IL-6, and IL-10 [（0.38±0.08）ng/L, （25.29±4.29）pg/L and （0.091±0.005）μg/L] in upper lobe CAP patients were higher than those in upper lobe tuberculosis patients[（0.05±0.01）ng/L, （10.55±2.71）pg/L and （0.027±0.002）μg/L]. The differences of PCT, IL-6 and IL-10 were statistically significant (P<0.05). Conclusions The laboratory examination of serum PCT, IL-6 and IL-10 are important clinical implications,at early stages, for the differential diagnosis of the upper lobe CAP and upper lobe pulmonary tuberculosis.