全身机械振动对去势骨质疏松大鼠血流变异常状态的干预作用

目的探讨全身机械振动对去势骨质疏松大鼠血液流变学指标的影响。方法 24只7月龄SD雌性大鼠随机分成对照组、模型组、全身振动组、福美加组。治疗8周后,收集左侧股骨和全血分别行骨矿含量、骨密度和血液流变学检测。结果模型组的骨矿含量和骨密度低于对照组(P0.05),对照组与福美加组骨密度高于模型组和全身振动组(P0.05),而全身振动组高于模型组(P0.05)。模型组200/S、30/S、3/S、TK、IR、EPT高于对照组(P0.05),全身振动组30/S低于模型组(P0.05),与对照组比较无统计学差异。结论去势大鼠存在血流变异常反应,全身机械振动可改善全血中切粘度30/S异常状态,提高骨矿含量和骨密度。

Effect of general mechanical vibration on abnormal hemorheology status in ovariectomized osteoporotic rats

Objective To investigate the effect of general mechanical vibration on hemorheology in ovariectomized osteoporotic rats.Methods Twenty-four 7-month female SD rats were randomly divided into 4 groups:control group, ovariectomized group, general mechanical vibration group, and Fumeijia group.After 8-week treatment, the bone mineral density ( BMD) and the bone mineral content ( BMC) of the left femur was detected.Hemorheology detection was also performed.Results BMC and BMD in ovariectomized group were significantly lower than those in control group (P<0.05).BMD in control group and Fumeijia group was significantly higher than that in ovariectomized group and general mechanical vibration group ( P<0.05 ) .BMD in general mechanical vibration group was higher than that in ovariectomized group ( P<0.05 ) .Compared with that in control group, the levels of 200/S, 30/S, 3/S, TK, IR, and EPT in ovariectomized group increased significantly (P<0.05).The level of 30/s in general mechanical vibration group was lower than that in ovariectomized group (P<0.05).Compared with that in control group, no significant difference was observed.Conclusion The hemorheology in ovariectomized rats is abnormal.The general mechanical vibration can improve the abnormal viscosity of 30/s in whole blood, and increase BMD and BMC in variectomized rats.